Endocrine Abstracts

Context: Previous studies suggest that total testosterone levels influences lipid metabolism. It has not been investigated whether these levels are prospectively associated with an unfavourable lipid profile including increased risk of incident dyslipidemia.Design and setting: We used data of 1468 men aged 20–79 years, repeatedly examined in the population-based Study of Health in Pomerania. Serum total testosterone levels, measured by chemiluminesc...

Background: Acromegaly is associated with increased morbidity and mortality from cardiovascular disease. Several studies indicate that reduction of growth hormone (GH) to <1 μg/l or normalization of serum IGF-I reduces mortality to expected levels. Inflammatory markers, such as C-reactive protein (CRP) or haemostatic markers, such as fibrinogen have emerged as important cardiovascular risk markers in the general population.Objective and design: ...

Background: Prospective studies showed that low serum testosterone concentrations are associated with various cardiometabolic risk factors and mortality. But the causal nature of these associations is controversial.Methods: We studied 1882 men aged 20–79 years with serum testosterone concentrations and genotyping data from the longitudinal population-based Study of Health in Pomerania.Testosterone concentrations were cross-sec...

Aim: The aim of this analysis was to determine whether low serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels predict the development of metabolic syndrome (MetS) in men.Methods: Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospective cohort of adults aged 20–79 at baseline. Analyses were conducted in 1004 men without baseline MetS, defined by National Cholesterol Education Program Adult ...

Introduction: To date, associations between sex hormones and sleep were mainly investigated in small and selected patient-based samples. Thus, we examined a comprehensive panel of mass spectrometry-measured sex hormones and various sleep characteristics in a population-based sample of healthy men and women from the general population.Methods: We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania TREND, who underwent ...

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...